Product Design Engineering (PDE) provides stakeholders with the ultimate product design engineering’s prioritizing outcome toward the human-centered and the sustainability of the product within realistic constraint. The priorities are aligned with the local wisdom of Industrial Revolution 4.0 (IR 4.0) in Indonesia, recognized as Making Indonesia 4.0. PDE in BINUS ASO School Engineering (BASE). It integrates the program Making Indonesia 4.0 with Japanese wisdom of Society 5.0. In wider perspective, PDE in BASE generates holistic approach of Breakthrough, Agility, Sustainability and Empowerment.